Transcutaneous electrical nerve stimulation (TENS) can be a surface-applied device that provides small voltage electrical current through the pores and skin to make analgesia.Developments during the knowledge of the cellular and molecular mechanisms of pain along with the features of pain have led to the discovery of novel therapeutic avenues for y… Read More

Even though the opiate receptor depends on G protein coupling for sign transduction, this receptor was uncovered to make use of arrestin activation for internalization on the receptor. If not, the receptor promoted no other signaling cascades (59) Modifications of conolidine have resulted in variable improvement in binding efficacy. This binding fi… Read More